微透析探头可用来探测在体和离体神经传递素和其它代谢物。多数情况下，这些探头被植入脑组织中，或者用于血液微透析中。

可以使用流动体系进行微透析实验，在流动体系中，溶液被泵流过微透析探头以富集代谢物，然后这些代谢物被填进探测器。在多数情况下使用电化学方法探测，因其高度的灵敏性，但从理论上讲也可以使用任何检测器例如荧光检测器或吸光度检测器。

PowerChrom和e-corder连用兼容绝大多数HPLC检测器，这些检测器包括电化学检测器可用于微透析的研究。以下公司生产电化学检测器：

e-corder系统可以使用Chart软件或PowerChrom软件来记录数据。PowerChrom 280和285系统使用PowerChrom软件和专用的数据记录硬件。(PowerChrom 285系统甚至具有内置的PC计算机，预装Window XP和PowerChrom色谱工作站软件)。

有些情况下，可以在微透析探头内部进行电化学检测。请参考：

这种电极有几种不同的配置型号，有离体使用的，也有在体使用的。可以将溶液通过泵驱动流经微透析电极，或者在静止的溶液中使用微透析电极。这些电极连接到：

Changes in inhibitory amino acid release linked to pontine-induced atonia:
An in vivo microdialysis study.

The concentration of amino acid in the perfusate was determined by HPLC (EDT-300; Eicom) witha fluorescence detector (excitation at 340 nm, emission at 440 nm) and quantified with a PowerChrom system.

Dynamic Changes in Glucose and Lactate in the Cortex of the Freely Moving Rat Monitored Using Microdialysis.

Dialysate was analysed on-line for glucose and lactate using a dual on-line assay. The assay is based on immobilised enzyme bed/ferrocene-mediated detection technology. A buffer (pH 7) containing the ferrocene monocarboxylic acid mediator is continuously pumped into the valve at a flow rate of 0.6 mL/min using an HPLC pump. Each assay system consists of a small enzyme bed reactor (1 mm x 20 mm, containing either glucose oxidase and horseradish peroxidase or lactate oxidase and horseradish peroxidase) and a downstream glassy carbon radial flow electrode held at -100 mV relative to an Ag/AgCl reference electrode. Valve switching and data collection were done using PowerChrom software.

Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo.

Stimulation of dopamine (DA) secretion in the NAcc by systemic nicotine was inhibited by selectively administering a-bungarotoxin or methyllycaconitine directly into this region, whereas mecamylamine was ineffective. In vivo microdialysis of accumbal dopamine secretion and receptor antagonist blockade in both the ventral striatal nucleus accumbens and the midbrain ventral tegmental area were used. Microdialysates were analysed by an ESA Coulochem II 5200A electrochemical detector with an ESA 5041 high-sensitivity analytical cell. Electrochemical detection was performed ata potential of 220 mV with the current gain at 10 nA. Under these conditions, the limit of detection for DA was 100 fg per injection. Chromatographic data were collected and analysed with a PowerChrom system.

Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum.

Nitric oxide production was estimated by the quantitation of nitrite/nitrate, the non-enzymatic oxidative products of nitric oxide. The amount of nitrite/nitrate was quantitated with an automatic system equipped with a liquid chromatograph and a reactor for the Griess reaction (ENO-100, Eicom, Kyoto, Japan), whereby nitrate was reduced to nitrite witha cadmium column. The absorbance of the reactant was measured at 540 nm with a flow-through spectrophotometer (NOD-10, Eicom). Data were collected and analysed with a Powerchrom system.